Safety and Tolerability

Safety & Tolerability

Easy on the Stomach

Who wants a therapy that brings on a lot of uncomfortable side effects? Ferralet® 90 contains carbonyl iron. Carbonyl iron has been shown to be lower in toxicity due to its slow absorption rate.1 In fact, in one study, carbonyl iron was given at 10 times the dose of ferrous sulfate. The two therapies were compared, and even at the greatly increased dose, the carbonyl iron showed no significant difference in GI side effects.1

Results like these are impressive. So much so, in fact, that a well-known medical textbook called Conn's Current Therapy 2008 asserts that carbonyl iron is recommended for most people.2

Accidental Poisoning in Children

Let's face it, as vigilant as we try to be, children sometimes get into places they shouldn't. Accidental iron overdose can be very dangerous, even fatal, to small children. Carbonyl iron is widely recognized as a safer choice, and in one study was shown to be 250 to 300 times as safe as ferrous sulfate because of carbonyl iron's slower rate of absorption.3 This is one reason why, when the Food and Drug Administration required iron products to be packaged in single-dose containers, carbonyl iron was singled out as the only iron that was given an exception to the requirement.4

1 Gordeuk VR, Brittenham GM, Hughes M, Keating LJ, Opplt JJ. High-dose carbonyl iron for iron deficiency anemia: a randomized double-blind trial. Am J Clin Nutr. 1987;46(6):1029-1034.

2 Barton JC. Iron deficiency. In: Rakel RE, Bope ET, eds. Conn’s Current Therapy. Amsterdam, the Netherlands: Saunders/Elsevier; 2008:385-389.

3 Brittenham GM, Klein HG, Kushner JP, Ajioka RS. Preserving the national blood supply. Hematol Am Soc Hematol Educ Program. 2001:422-432.

4 US National Archives and Records Administration. Rules and regulations. Iron-containing supplements and drugs: label warning statements and unit-dose packaging requirements. Fed Regist. 1997;62(10):2239.